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Course Information

Year 2012  School School of Education
Course Title
Special Lecture of Biology VII

Instructor QUINN, Gary
Term/Day/Period first semester  Wed.2
Category Science (Biology) Eligible Year 2nd year and above Credits 2
Classroom 16-701 Campus waseda
Course Key 1505020006 Course Class Code 01
Main Language English

Syllabus Information

Latest Update:2012/03/08 19:37:17

Subtitle Regenerative Medicine and the Treatment of Type I Diabetes Mellitus
Course Outline

Regenerative medicine promises to treat many human diseases through either a) stimulating the body’s own (endogenous) tissues to undergo repair and regeneration in vivo or b) transplantation of cells and tissues (exogenous) that have been manipulated in vitro to restore normal health.

Stem cells, particularly embryonic stem cells (ES cells) are a key resource for regenerative medicine. ES cells are pluripotent, i.e. they have the potential to differentiate into almost any tissue of the body. They are also immortal, i.e. they can divide indefinitely. Thus ES cells are a key resource for type b) regenerative medicine. In addition, it is believed that ES cells can secrete chemical factors (e.g. cytokines) that can stimulate the body’s own, endogenous, cells to grow and recover.Therefore ES cells have potential for type a) regenerative medicine also.

In this 16-week lecture course we will look at the case of regenerative medicine, using ES cells, to treat Type I Diabetes Mellitus, a major disease caused by loss of the insulin-producing pancreatic beta cells. We will discuss methods of inducing diabetes in animal models and then discuss regenerative medicine approaches to cure those animals, and various techniques to monitor pancreatic regeneration. Finally we will examine the molecular mechanisms that underlie the therapeutic effect and draw comparisons between pancreatic regeneration in the adult and the process of pancreatic development in the embryo.

Objectives 1. To provide some insight into the potential of regenerative medicine to a) cure diseases and b) tell us something about the body’s mechanisms for repairing damaged tissues.

2. Specifically, to see how regenerative medicine might be effective to treat diabetes.

3. To observe how a laboratory research project can develop over the course of 3 successive research publications, each one building upon the results of the previous one.
Course Schedule

Summary of 2012 lecture course:

 

Week 1: introduction – regenerativemedicine and ES cells

 

Weeks 2 – 6: IP injection of ES cells anddetermination of pancreas differentiation in ES tumours

 

                Week2/3: Title, aims, introduction and methodology

                Week4/5: Results and discussion

                Week6: Written exam involving answers to questions based on paper

 

Weeks 7 – 11: Kidney capsule transplantation of ES cells and in situ differentiation of cells in tumours

 

Week 7/8: Title, aims, introduction and methodology

                Week9/10: Results and discussion

                Week11: Written exam involving answers to questions based on paper

 

 

Weeks 12 – 16: Kidney capsule transplantation of ES cells and analysis of pancreas regeneration in the pancreas organ itself

 

Week 12/13:Title, aims, introduction and methodology

                Week14/15: Results and discussion

                Week16: Written exam involving answers to questions based on paper

Reference 1. Kodama M, Yoshida K, Aoki K, Tsukamoto K and Quinn G: Embryonic stem cell transplantation promotes endogenous neurogenin 3 expression and whole tissue regeneration in streptozocin injured mice. Journal of Histochemistry and Cytochemistry (2009) 57, 1149-58

2. Kodama M, Takeshita F, Kanegasaki S, Ochiya T and Quinn G: Pancreatic Endocrine and Exocrine Cell Ontogeny from Renal Capsule-Transplanted Embryonic Stem cells in Streptozocin-Injured Mice. Journal of Histochemistry and Cytochemistry (2008) 56, 33-44

3. Takeshita F, Kodama M, Ueda S, Yamamoto H, Teratani T, Yamamoto Y, Igarashi Y, Tamatani T, Kanegasaki S and Ochiya T and Quinn G: Streptozocin-induced partial β cell depletion in nude mice without hyperglycemia induces pancreatic morphogenesis in transplanted embyronic stem cells. Diabetologia (2006) 49, 2948-58
Evaluation During the class of weeks 6,11 and 16 there will be a written examination based on the previous 4 lectures. This will count for 100% of credit.
Related Materials
Title Publication Date
Embryonic stem cell transplantation promotes endogenous neurogenin 3 expression and whole tissue regeneration in streptozocin injured mice. 2012/02/04 13:30:19
Pancreatic Endocrine and Exocrine Cell Ontogeny from Renal Capsule-Transplanted Embryonic Stem cells in Streptozocin-Injured Mice. 2012/02/04 13:28:11
Streptozocin-induced partial β cell depletion in nude mice without hyperglycemia induces pancreatic morphogenesis in transplanted embyronic stem cells 2012/02/04 13:26:46

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